serious and sometimes fatal events can occur, such as infections, cancer in children and adults, heart failure, nervous system disorders, liver or blood problems, and allergic reactions. before starting simponi™, your doctor should test you for tb and assess your risk of infections, including fungal infections and hepatitis b. ask your doctor if you've been to a region where certain fungal infections are common. tell your doctor if you're prone to infections, or develop symptoms such as fever, fatigue, cough, or sores. you should not start simponi™ if you have an infection. [ female announcer ] ask your rheumatologist about simponi™. just one dose, once a month. there's no way to hide it. sir, have you been drinking tonight? if you ride drunk, you will get caught... and you will get arrested.